About Transmembrane protein 45B
Transmembrane protein 45B (TMEM45B) is a protein
from Homo sapiens identified by UniProt accession
Q96B21, 275 residues long.
MolForge cross-references it against 0 known binders and
48 disease associations.
Target properties
| Protein name | Transmembrane protein 45B |
|---|
| UniProt accession | Q96B21 |
|---|
| Gene | TMEM45B |
|---|
| Organism | Homo sapiens |
|---|
| Length | 275 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (48)
Diseases linked to this target (Open Targets).
- hair colour measurement · score 0.24
- serum metabolite measurement · score 0.22
- breast carcinoma · score 0.21
- Red cell distribution width · score 0.03
- neoplasm · score 0.02
- psoriasis · score 0.02
- reticulocyte measurement · score 0.02
- DNA methylation · score 0.02
- PHF-tau measurement · score 0.02
- cystatin C measurement · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96B21-F1 | alphafold | PREDICTED | 90.78 | — |
Amino-acid sequence (275 residues)
MANFKGHALP GSFFLIIGLC WSVKYPLKYF SHTRKNSPLH YYQRLEIVEA AIRTLFSVTG ILAEQFVPDG PHLHLYHENH WIKLMNWQHS TMYLFFAVSG IVDMLTYLVS HVPLGVDRLV MAVAVFMEGF LFYYHVHNRP PLDQHIHSLL LYALFGGCVS ISLEVIFRDH IVLELFRTSL IILQGTWFWQ IGFVLFPPFG TPEWDQKDDA NLMFITMCFC WHYLAALSIV AVNYSLVYCL LTRMKRHGRG EIIGIQKLNS DDTYQTALLS GSDEE
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