Transmembrane protein 45B (TMEM45B)
Homo sapiens — UniProt Q96B21
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 45B (TMEM45B) is a protein from Homo sapiens identified by UniProt accession Q96B21, 275 residues long. MolForge cross-references it against 0 known binders and 48 disease associations.
- UniProt accession: Q96B21; gene symbol TMEM45B.
- Organism: Homo sapiens.
- Length: 275 amino acids.
- Top disease associations (Open Targets): hair colour measurement, serum metabolite measurement and breast carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 45B |
|---|---|
| UniProt accession | Q96B21 |
| Gene | TMEM45B |
| Organism | Homo sapiens |
| Length | 275 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (48)
Diseases linked to this target (Open Targets).
- hair colour measurement · score 0.24
- serum metabolite measurement · score 0.22
- breast carcinoma · score 0.21
- Red cell distribution width · score 0.03
- neoplasm · score 0.02
- psoriasis · score 0.02
- reticulocyte measurement · score 0.02
- DNA methylation · score 0.02
- PHF-tau measurement · score 0.02
- cystatin C measurement · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96B21-F1 | alphafold | PREDICTED | 90.78 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96B21.
Amino-acid sequence (275 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM45B?
The strongest Open Targets associations for TMEM45B are hair colour measurement, serum metabolite measurement, breast carcinoma, Red cell distribution width and neoplasm.
How long is the TMEM45B protein?
The Homo sapiens TMEM45B protein (UniProt Q96B21) is 275 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96B21 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96B21 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.