E3 ubiquitin-protein ligase RNF25 (RNF25)
Homo sapiens — UniProt Q96BH1
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase RNF25 (RNF25) is a protein from Homo sapiens identified by UniProt accession Q96BH1, 459 residues long. MolForge cross-references it against 0 known binders and 53 disease associations.
- UniProt accession: Q96BH1; gene symbol RNF25.
- Organism: Homo sapiens.
- Length: 459 amino acids.
- Top disease associations (Open Targets): clear cell renal carcinoma, acute myeloid leukemia and reticulocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase RNF25 |
|---|---|
| UniProt accession | Q96BH1 |
| Gene | RNF25 |
| Organism | Homo sapiens |
| Length | 459 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (53)
Diseases linked to this target (Open Targets).
- clear cell renal carcinoma · score 0.18
- acute myeloid leukemia · score 0.10
- reticulocyte count · score 0.10
- body height · score 0.09
- triglyceride measurement · score 0.08
- hepatocellular carcinoma · score 0.08
- IGF-1 measurement · score 0.06
- bilirubin measurement · score 0.05
- sex hormone-binding globulin measurement · score 0.05
- diastolic blood pressure · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96BH1-F1 | alphafold | PREDICTED | 67.69 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96BH1.
Amino-acid sequence (459 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RNF25?
The strongest Open Targets associations for RNF25 are clear cell renal carcinoma, acute myeloid leukemia, reticulocyte count, body height and triglyceride measurement.
How long is the RNF25 protein?
The Homo sapiens RNF25 protein (UniProt Q96BH1) is 459 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96BH1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96BH1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.