Primary cilium assembly protein FAM149B1 (FAM149B1)
Homo sapiens — UniProt Q96BN6
Data last refreshed: (UniProt release unknown)
Key facts
Primary cilium assembly protein FAM149B1 (FAM149B1) is a protein from Homo sapiens identified by UniProt accession Q96BN6, 582 residues long. MolForge cross-references it against 0 known binders and 82 disease associations.
- UniProt accession: Q96BN6; gene symbol FAM149B1.
- Organism: Homo sapiens.
- Length: 582 amino acids.
- Top disease associations (Open Targets): Joubert syndrome 36, neurodegenerative disease and orofaciodigital syndrome type 6.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Primary cilium assembly protein FAM149B1 |
|---|---|
| UniProt accession | Q96BN6 |
| Gene | FAM149B1 |
| Organism | Homo sapiens |
| Length | 582 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (82)
Diseases linked to this target (Open Targets).
- Joubert syndrome 36 · score 0.60
- neurodegenerative disease · score 0.44
- orofaciodigital syndrome type 6 · score 0.37
- syndromic intellectual disability · score 0.37
- Joubert syndrome · score 0.33
- orofaciodigital syndrome · score 0.26
- serum alanine aminotransferase measurement · score 0.14
- azoospermia · score 0.09
- Male infertility with spermatogenesis disorder due to single gene mutation · score 0.07
- Female infertility due to fertilization defect · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96BN6-F1 | alphafold | PREDICTED | 51.98 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96BN6.
Amino-acid sequence (582 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FAM149B1?
The strongest Open Targets associations for FAM149B1 are Joubert syndrome 36, neurodegenerative disease, orofaciodigital syndrome type 6, syndromic intellectual disability and Joubert syndrome.
How long is the FAM149B1 protein?
The Homo sapiens FAM149B1 protein (UniProt Q96BN6) is 582 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96BN6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96BN6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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