Coiled-coil domain-containing protein 127 (CCDC127)
Homo sapiens — UniProt Q96BQ5
Data last refreshed: (UniProt release unknown)
Key facts
Coiled-coil domain-containing protein 127 (CCDC127) is a protein from Homo sapiens identified by UniProt accession Q96BQ5, 260 residues long. MolForge cross-references it against 0 known binders and 23 disease associations.
- UniProt accession: Q96BQ5; gene symbol CCDC127.
- Organism: Homo sapiens.
- Length: 260 amino acids.
- Top disease associations (Open Targets): mitochondrial disease, Leigh syndrome and adrenal gland pheochromocytoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Coiled-coil domain-containing protein 127 |
|---|---|
| UniProt accession | Q96BQ5 |
| Gene | CCDC127 |
| Organism | Homo sapiens |
| Length | 260 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (23)
Diseases linked to this target (Open Targets).
- mitochondrial disease · score 0.12
- Leigh syndrome · score 0.12
- adrenal gland pheochromocytoma · score 0.12
- mitochondrial complex II deficiency, nuclear type 1 · score 0.12
- BMI-adjusted hip circumference · score 0.05
- body weight · score 0.05
- DNA methylation · score 0.04
- fat body mass · score 0.04
- BMI-adjusted waist circumference · score 0.04
- body height · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96BQ5-F1 | alphafold | PREDICTED | 87.00 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96BQ5.
Amino-acid sequence (260 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CCDC127?
The strongest Open Targets associations for CCDC127 are mitochondrial disease, Leigh syndrome, adrenal gland pheochromocytoma, mitochondrial complex II deficiency, nuclear type 1 and BMI-adjusted hip circumference.
How long is the CCDC127 protein?
The Homo sapiens CCDC127 protein (UniProt Q96BQ5) is 260 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96BQ5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96BQ5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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