Serine/threonine-protein kinase Sgk3 (SGK3)
Homo sapiens — UniProt Q96BR1
Data last refreshed: (UniProt release unknown)
Key facts
Serine/threonine-protein kinase Sgk3 (SGK3) is a protein from Homo sapiens identified by UniProt accession Q96BR1, 496 residues long. MolForge cross-references it against 5 known binders and 214 disease associations.
- UniProt accession: Q96BR1; gene symbol SGK3.
- Organism: Homo sapiens.
- Length: 496 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, Alzheimer disease and lysosomal storage disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Serine/threonine-protein kinase Sgk3 |
|---|---|
| UniProt accession | Q96BR1 |
| Gene | SGK3 |
| Organism | Homo sapiens |
| Length | 496 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (214)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.38
- Alzheimer disease · score 0.24
- lysosomal storage disease · score 0.24
- Parkinson disease · score 0.24
- multiple sclerosis · score 0.24
- neuroinflammatory disorder · score 0.16
- breast adenocarcinoma · score 0.16
- gut microbiome measurement · score 0.13
- head and neck squamous cell carcinoma · score 0.12
- prostate carcinoma · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96BR1-F1 | alphafold | PREDICTED | 83.37 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96BR1.
Amino-acid sequence (496 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SGK3?
The strongest Open Targets associations for SGK3 are neurodegenerative disease, Alzheimer disease, lysosomal storage disease, Parkinson disease and multiple sclerosis.
How long is the SGK3 protein?
The Homo sapiens SGK3 protein (UniProt Q96BR1) is 496 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96BR1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96BR1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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