Cytochrome c oxidase assembly factor 7 (COA7)
Homo sapiens — UniProt Q96BR5
Data last refreshed: (UniProt release unknown)
Key facts
Cytochrome c oxidase assembly factor 7 (COA7) is a protein from Homo sapiens identified by UniProt accession Q96BR5, 231 residues long. MolForge cross-references it against 0 known binders and 29 disease associations.
- UniProt accession: Q96BR5; gene symbol COA7.
- Organism: Homo sapiens.
- Length: 231 amino acids.
- Top disease associations (Open Targets): spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 3, cystatin C measurement and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cytochrome c oxidase assembly factor 7 |
|---|---|
| UniProt accession | Q96BR5 |
| Gene | COA7 |
| Organism | Homo sapiens |
| Length | 231 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (29)
Diseases linked to this target (Open Targets).
- spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 3 · score 0.80
- cystatin C measurement · score 0.30
- genetic disorder · score 0.17
- mean reticulocyte volume · score 0.02
- hyperinsulinemic hypoglycemia, familial, 4 · score 0.01
- Ataxia · score 0.01
- Brain atrophy · score 0.01
- axonal neuropathy · score 0.01
- malaria · score 0.01
- Parkinsonism · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96BR5-F1 | alphafold | PREDICTED | 95.34 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96BR5.
Amino-acid sequence (231 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with COA7?
The strongest Open Targets associations for COA7 are spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 3, cystatin C measurement, genetic disorder, mean reticulocyte volume and hyperinsulinemic hypoglycemia, familial, 4.
How long is the COA7 protein?
The Homo sapiens COA7 protein (UniProt Q96BR5) is 231 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96BR5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96BR5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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