tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ALKBH8 (ALKBH8)
Homo sapiens — UniProt Q96BT7
Data last refreshed: (UniProt release unknown)
Key facts
tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ALKBH8 (ALKBH8) is a protein from Homo sapiens identified by UniProt accession Q96BT7, 664 residues long. MolForge cross-references it against 0 known binders and 57 disease associations.
- UniProt accession: Q96BT7; gene symbol ALKBH8.
- Organism: Homo sapiens.
- Length: 664 amino acids.
- Top disease associations (Open Targets): intellectual developmental disorder, autosomal recessive 71, neurodegenerative disease and autosomal recessive non-syndromic intellectual disability.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ALKBH8 |
|---|---|
| UniProt accession | Q96BT7 |
| Gene | ALKBH8 |
| Organism | Homo sapiens |
| Length | 664 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (57)
Diseases linked to this target (Open Targets).
- intellectual developmental disorder, autosomal recessive 71 · score 0.72
- neurodegenerative disease · score 0.46
- autosomal recessive non-syndromic intellectual disability · score 0.37
- PHF-tau measurement · score 0.22
- Adult-onset autosomal recessive sideroblastic anemia · score 0.05
- dehydrated hereditary stomatocytosis · score 0.05
- hemoglobin E-beta-thalassemia syndrome · score 0.05
- microcytic anemia with liver iron overload · score 0.04
- hemoglobin D disease · score 0.04
- thrombocytopenia 4 · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96BT7-F1 | alphafold | PREDICTED | 80.54 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96BT7.
Amino-acid sequence (664 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ALKBH8?
The strongest Open Targets associations for ALKBH8 are intellectual developmental disorder, autosomal recessive 71, neurodegenerative disease, autosomal recessive non-syndromic intellectual disability, PHF-tau measurement and Adult-onset autosomal recessive sideroblastic anemia.
How long is the ALKBH8 protein?
The Homo sapiens ALKBH8 protein (UniProt Q96BT7) is 664 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96BT7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96BT7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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