Phosphatidate cytidylyltransferase, mitochondrial…

About Phosphatidate cytidylyltransferase, mitochondrial

Phosphatidate cytidylyltransferase, mitochondrial (TAMM41) is a protein from Homo sapiens identified by UniProt accession Q96BW9, 452 residues long. MolForge cross-references it against 0 known binders and 42 disease associations.

Target properties

Protein name	Phosphatidate cytidylyltransferase, mitochondrial
UniProt accession	Q96BW9
Gene	TAMM41
Organism	Homo sapiens
Length	452 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (42)

Diseases linked to this target (Open Targets).

Bilateral ptosis · score 0.47
catecholaminergic polymorphic ventricular tachycardia · score 0.42
gastroesophageal reflux disease · score 0.42
Abnormal facial shape · score 0.42
respiratory failure · score 0.42
Dysphagia · score 0.42
Neonatal hypotonia · score 0.42
neurodegenerative disease · score 0.23
sphingomyelin measurement · score 0.06
metabolite measurement · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96BW9-F1	alphafold	PREDICTED	73.28	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96BW9.

Amino-acid sequence (452 residues)

MALQTLQSSW VTFRKILSHF PEELSLAFVY GSGVYRQAGP SSDQKNAMLD FVFTVDDPVA WHSKNLKKNW SHYSFLKVLG PKIITSIQNN YGAGVYYNSL IMCNGRLIKY GVISTNVLIE DLLNWNNLYI AGRLQKPVKI ISVNEDVTLR SALDRNLKSA VTAAFLMLPE SFSEEDLFIE IAGLSYSGDF RMVVGEDKTK VLNIVKPNIA HFRELYGSIL QENPQVVYKS QQGWLEIDKS PEGQFTQLMT LPKTLQQQIN HIMDPPGKNR DVEETLFQVA HDPDCGDVVR LGLSAIVRPS SIRQSTKGIF TAGKSFGNPC VTYLLTEWLP HSWLQCKALY LLGACEMLSF DGHKLGYCSK VQTGITAAEP GGRTMSDHWQ CCWKLYCPSE FSETLPVCRV FPSYCFIYQS YRCIGLQKQQ HLCSPSSSPS LRQLLPSVLV GYFCCYCHFS KW

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Phosphatidate cytidylyltransferase, mitochondrial (TAMM41)