5'-3' exonuclease PLD4 (PLD4)
Homo sapiens — UniProt Q96BZ4
Data last refreshed: (UniProt release unknown)
Key facts
5'-3' exonuclease PLD4 (PLD4) is a protein from Homo sapiens identified by UniProt accession Q96BZ4, 506 residues long. MolForge cross-references it against 0 known binders and 283 disease associations.
- UniProt accession: Q96BZ4; gene symbol PLD4.
- Organism: Homo sapiens.
- Length: 506 amino acids.
- Top disease associations (Open Targets): rheumatoid arthritis, glioblastoma multiforme and endometrial cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | 5'-3' exonuclease PLD4 |
|---|---|
| UniProt accession | Q96BZ4 |
| Gene | PLD4 |
| Organism | Homo sapiens |
| Length | 506 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (283)
Diseases linked to this target (Open Targets).
- rheumatoid arthritis · score 0.28
- glioblastoma multiforme · score 0.27
- endometrial cancer · score 0.26
- breast adenocarcinoma · score 0.26
- cutaneous melanoma · score 0.18
- blood protein measurement · score 0.14
- systemic lupus erythematosus · score 0.09
- Systemic lupus erythematosus · score 0.08
- autoimmune lymphoproliferative syndrome type 4 · score 0.06
- immunodeficiency 72 with autoinflammation · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96BZ4-F1 | alphafold | PREDICTED | 86.24 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96BZ4.
Amino-acid sequence (506 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PLD4?
The strongest Open Targets associations for PLD4 are rheumatoid arthritis, glioblastoma multiforme, endometrial cancer, breast adenocarcinoma and cutaneous melanoma.
How long is the PLD4 protein?
The Homo sapiens PLD4 protein (UniProt Q96BZ4) is 506 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96BZ4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96BZ4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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