About Synaptotagmin-like protein 4
Synaptotagmin-like protein 4 (SYTL4) is a protein
from Homo sapiens identified by UniProt accession
Q96C24, 671 residues long.
MolForge cross-references it against 0 known binders and
87 disease associations.
Target properties
| Protein name | Synaptotagmin-like protein 4 |
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| UniProt accession | Q96C24 |
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| Gene | SYTL4 |
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| Organism | Homo sapiens |
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| Length | 671 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (87)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.25
- neuroinflammatory disorder · score 0.18
- glioblastoma multiforme · score 0.14
- MODY · score 0.11
- type 2 diabetes mellitus · score 0.09
- diabetes mellitus, transient neonatal, 2 · score 0.08
- triple-negative breast cancer · score 0.07
- type 1 diabetes mellitus · score 0.07
- growth hormone-secreting pituitary adenoma · score 0.07
- Pituitary Gland Adenoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96C24-F1 | alphafold | PREDICTED | 67.84 | — |
Amino-acid sequence (671 residues)
MSELLDLSFL SEEEKDLILS VLQRDEEVRK ADEKRIRRLK NELLEIKRKG AKRGSQHYSD RTCARCQESL GRLSPKTNTC RGCNHLVCRD CRIQESNGTW RCKVCAKEIE LKKATGDWFY DQKVNRFAYR TGSEIIRMSL RHKPAVSKRE TVGQSLLHQT QMGDIWPGRK IIQERQKEPS VLFEVPKLKS GKSALEAESE SLDSFTADSD STSRRDSLDK SGLFPEWKKM SAPKSQVEKE TQPGGQNVVF VDEGEMIFKK NTRKILRPSE YTKSVIDLRP EDVVHESGSL GDRSKSVPGL NVDMEEEEEE EDIDHLVKLH RQKLARSSMQ SGSSMSTIGS MMSIYSEAGD FGNIFVTGRI AFSLKYEQQT QSLVVHVKEC HQLAYADEAK KRSNPYVKTY LLPDKSRQGK RKTSIKRDTI NPLYDETLRY EIPESLLAQR TLQFSVWHHG RFGRNTFLGE AEIQMDSWKL DKKLDHCLPL HGKISAESPT GLPSHKGELV VSLKYIPASK TPVGGDRKKS KGGEGGELQV WIKEAKNLTA AKAGGTSDSF VKGYLLPMRN KASKRKTPVM KKTLNPHYNH TFVYNGVRLE DLQHMCLELT VWDREPLASN DFLGGVRLGV GTGISNGEVV DWMDSTGEEV SLWQKMRQYP GSWAEGTLQL RSSMAKQKLG L
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