G-protein coupled receptor 146 (GPR146)

About G-protein coupled receptor 146

G-protein coupled receptor 146 (GPR146) is a protein from Homo sapiens identified by UniProt accession Q96CH1, 333 residues long. MolForge cross-references it against 0 known binders and 186 disease associations.

Target properties

Protein name	G-protein coupled receptor 146
UniProt accession	Q96CH1
Gene	GPR146
Organism	Homo sapiens
Length	333 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (186)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.30
mean corpuscular volume · score 0.26
blood protein measurement · score 0.25
high density lipoprotein cholesterol measurement · score 0.20
apolipoprotein A 1 measurement · score 0.19
mean corpuscular hemoglobin concentration · score 0.19
reticulocyte measurement · score 0.18
reticulocyte count · score 0.18
total cholesterol measurement · score 0.17
low density lipoprotein cholesterol measurement · score 0.16

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96CH1-F1	alphafold	PREDICTED	78.06	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96CH1.

Amino-acid sequence (333 residues)

MWSCSWFNGT GLVEELPACQ DLQLGLSLLS LLGLVVGVPV GLCYNALLVL ANLHSKASMT MPDVYFVNMA VAGLVLSALA PVHLLGPPSS RWALWSVGGE VHVALQIPFN VSSLVAMYST ALLSLDHYIE RALPRTYMAS VYNTRHVCGF VWGGALLTSF SSLLFYICSH VSTRALECAK MQNAEAADAT LVFIGYVVPA LATLYALVLL SRVRREDTPL DRDTGRLEPS AHRLLVATVC TQFGLWTPHY LILLGHTVII SRGKPVDAHY LGLLHFVKDF SKLLAFSSSF VTPLLYRYMN QSFPSKLQRL MKKLPCGDRH CSPDHMGVQQ VLA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards