Leucine-rich repeat-containing protein 45 (LRRC45)
Homo sapiens — UniProt Q96CN5
Data last refreshed: (UniProt release unknown)
Key facts
Leucine-rich repeat-containing protein 45 (LRRC45) is a protein from Homo sapiens identified by UniProt accession Q96CN5, 670 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.
- UniProt accession: Q96CN5; gene symbol LRRC45.
- Organism: Homo sapiens.
- Length: 670 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, vital capacity and body height.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Leucine-rich repeat-containing protein 45 |
|---|---|
| UniProt accession | Q96CN5 |
| Gene | LRRC45 |
| Organism | Homo sapiens |
| Length | 670 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (21)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.28
- vital capacity · score 0.24
- body height · score 0.17
- BMI-adjusted hip circumference · score 0.16
- BMI-adjusted waist-hip ratio · score 0.15
- FEV/FVC ratio · score 0.12
- appendicular lean mass · score 0.09
- parental genotype effect measurement · score 0.08
- birth weight · score 0.08
- heel bone mineral density · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96CN5-F1 | alphafold | PREDICTED | 83.36 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96CN5.
Amino-acid sequence (670 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LRRC45?
The strongest Open Targets associations for LRRC45 are neurodegenerative disease, vital capacity, body height, BMI-adjusted hip circumference and BMI-adjusted waist-hip ratio.
How long is the LRRC45 protein?
The Homo sapiens LRRC45 protein (UniProt Q96CN5) is 670 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96CN5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96CN5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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