Voltage-gated hydrogen channel 1 (HVCN1)
Homo sapiens — UniProt Q96D96
Data last refreshed: (UniProt release unknown)
Key facts
Voltage-gated hydrogen channel 1 (HVCN1) is a protein from Homo sapiens identified by UniProt accession Q96D96, 273 residues long. MolForge cross-references it against 0 known binders and 131 disease associations.
- UniProt accession: Q96D96; gene symbol HVCN1.
- Organism: Homo sapiens.
- Length: 273 amino acids.
- Top disease associations (Open Targets): Joubert syndrome, Meckel syndrome and Joubert syndrome and related disorders.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Voltage-gated hydrogen channel 1 |
|---|---|
| UniProt accession | Q96D96 |
| Gene | HVCN1 |
| Organism | Homo sapiens |
| Length | 273 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (131)
Diseases linked to this target (Open Targets).
- Joubert syndrome · score 0.55
- Meckel syndrome · score 0.54
- Joubert syndrome and related disorders · score 0.38
- neurodegenerative disease · score 0.34
- cutaneous melanoma · score 0.25
- lung adenocarcinoma · score 0.23
- genetic disorder · score 0.19
- breast adenocarcinoma · score 0.16
- glioblastoma multiforme · score 0.15
- head and neck squamous cell carcinoma · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96D96-F1 | alphafold | PREDICTED | 69.77 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96D96.
Amino-acid sequence (273 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HVCN1?
The strongest Open Targets associations for HVCN1 are Joubert syndrome, Meckel syndrome, Joubert syndrome and related disorders, neurodegenerative disease and cutaneous melanoma.
How long is the HVCN1 protein?
The Homo sapiens HVCN1 protein (UniProt Q96D96) is 273 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96D96 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96D96 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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