Carboxymethylenebutenolidase homolog (CMBL)
Homo sapiens — UniProt Q96DG6
Data last refreshed: (UniProt release unknown)
Key facts
Carboxymethylenebutenolidase homolog (CMBL) is a protein from Homo sapiens identified by UniProt accession Q96DG6, 245 residues long. MolForge cross-references it against 0 known binders and 48 disease associations.
- UniProt accession: Q96DG6; gene symbol CMBL.
- Organism: Homo sapiens.
- Length: 245 amino acids.
- Top disease associations (Open Targets): viral load, diffuse plaque measurement and glioblastoma multiforme.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Carboxymethylenebutenolidase homolog |
|---|---|
| UniProt accession | Q96DG6 |
| Gene | CMBL |
| Organism | Homo sapiens |
| Length | 245 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (48)
Diseases linked to this target (Open Targets).
- viral load · score 0.16
- diffuse plaque measurement · score 0.16
- glioblastoma multiforme · score 0.16
- gut microbiome measurement · score 0.08
- Barrett's esophagus · score 0.05
- ovarian neoplasm · score 0.04
- esophageal adenocarcinoma · score 0.04
- Leishmaniasis · score 0.02
- small cell lung carcinoma · score 0.02
- visceral Leishmaniasis · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96DG6-F1 | alphafold | PREDICTED | 91.61 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96DG6.
Amino-acid sequence (245 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CMBL?
The strongest Open Targets associations for CMBL are viral load, diffuse plaque measurement, glioblastoma multiforme, gut microbiome measurement and Barrett's esophagus.
How long is the CMBL protein?
The Homo sapiens CMBL protein (UniProt Q96DG6) is 245 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96DG6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96DG6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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