Methionyl-tRNA formyltransferase, mitochondrial (MTFMT)
Homo sapiens — UniProt Q96DP5
Data last refreshed: (UniProt release unknown)
Key facts
Methionyl-tRNA formyltransferase, mitochondrial (MTFMT) is a protein from Homo sapiens identified by UniProt accession Q96DP5, 389 residues long. MolForge cross-references it against 0 known binders and 41 disease associations.
- UniProt accession: Q96DP5; gene symbol MTFMT.
- Organism: Homo sapiens.
- Length: 389 amino acids.
- Top disease associations (Open Targets): combined oxidative phosphorylation defect type 15, mitochondrial complex 1 deficiency, nuclear type 27 and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Methionyl-tRNA formyltransferase, mitochondrial |
|---|---|
| UniProt accession | Q96DP5 |
| Gene | MTFMT |
| Organism | Homo sapiens |
| Length | 389 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (41)
Diseases linked to this target (Open Targets).
- combined oxidative phosphorylation defect type 15 · score 0.80
- mitochondrial complex 1 deficiency, nuclear type 27 · score 0.77
- neurodegenerative disease · score 0.51
- mitochondrial complex I deficiency · score 0.48
- genetic disorder · score 0.47
- Leigh syndrome · score 0.45
- Inability to walk by childhood/adolescence · score 0.34
- Abnormal facial shape · score 0.34
- Poor speech · score 0.34
- Short stature · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96DP5-F1 | alphafold | PREDICTED | 86.24 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96DP5.
Amino-acid sequence (389 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MTFMT?
The strongest Open Targets associations for MTFMT are combined oxidative phosphorylation defect type 15, mitochondrial complex 1 deficiency, nuclear type 27, neurodegenerative disease, mitochondrial complex I deficiency and genetic disorder.
How long is the MTFMT protein?
The Homo sapiens MTFMT protein (UniProt Q96DP5) is 389 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96DP5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96DP5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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