Inositol-trisphosphate 3-kinase C (ITPKC)
Homo sapiens — UniProt Q96DU7
Data last refreshed: (UniProt release unknown)
Key facts
Inositol-trisphosphate 3-kinase C (ITPKC) is a protein from Homo sapiens identified by UniProt accession Q96DU7, 683 residues long. MolForge cross-references it against 0 known binders and 49 disease associations.
- UniProt accession: Q96DU7; gene symbol ITPKC.
- Organism: Homo sapiens.
- Length: 683 amino acids.
- Top disease associations (Open Targets): mucocutaneous lymph node syndrome, neurodegenerative disease and neuroinflammatory disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Inositol-trisphosphate 3-kinase C |
|---|---|
| UniProt accession | Q96DU7 |
| Gene | ITPKC |
| Organism | Homo sapiens |
| Length | 683 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (49)
Diseases linked to this target (Open Targets).
- mucocutaneous lymph node syndrome · score 0.42
- neurodegenerative disease · score 0.33
- neuroinflammatory disorder · score 0.24
- glioblastoma multiforme · score 0.23
- cutaneous melanoma · score 0.18
- breast adenocarcinoma · score 0.13
- basophil count · score 0.13
- monocyte count · score 0.11
- leukocyte count · score 0.09
- chronic obstructive pulmonary disease · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96DU7-F1 | alphafold | PREDICTED | 58.89 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96DU7.
Amino-acid sequence (683 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ITPKC?
The strongest Open Targets associations for ITPKC are mucocutaneous lymph node syndrome, neurodegenerative disease, neuroinflammatory disorder, glioblastoma multiforme and cutaneous melanoma.
How long is the ITPKC protein?
The Homo sapiens ITPKC protein (UniProt Q96DU7) is 683 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96DU7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96DU7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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