Sperm acrosome-associated protein 9 (SPACA9)
Homo sapiens — UniProt Q96E40
Data last refreshed: (UniProt release unknown)
Key facts
Sperm acrosome-associated protein 9 (SPACA9) is a protein from Homo sapiens identified by UniProt accession Q96E40, 222 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.
- UniProt accession: Q96E40; gene symbol SPACA9.
- Organism: Homo sapiens.
- Length: 222 amino acids.
- Top disease associations (Open Targets): lifestyle measurement, Red cell distribution width and mathematical ability.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sperm acrosome-associated protein 9 |
|---|---|
| UniProt accession | Q96E40 |
| Gene | SPACA9 |
| Organism | Homo sapiens |
| Length | 222 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (27)
Diseases linked to this target (Open Targets).
- lifestyle measurement · score 0.15
- Red cell distribution width · score 0.15
- mathematical ability · score 0.14
- self reported educational attainment · score 0.11
- urate measurement · score 0.11
- mean corpuscular volume · score 0.06
- mean corpuscular hemoglobin concentration · score 0.05
- Immature Reticulocyte Fraction Measurement · score 0.05
- mean reticulocyte volume · score 0.05
- mean platelet volume · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96E40-F1 | alphafold | PREDICTED | 80.29 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96E40.
Amino-acid sequence (222 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPACA9?
The strongest Open Targets associations for SPACA9 are lifestyle measurement, Red cell distribution width, mathematical ability, self reported educational attainment and urate measurement.
How long is the SPACA9 protein?
The Homo sapiens SPACA9 protein (UniProt Q96E40) is 222 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96E40 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96E40 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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