Protein Spindly (SPDL1)
Homo sapiens — UniProt Q96EA4
Data last refreshed: (UniProt release unknown)
Key facts
Protein Spindly (SPDL1) is a protein from Homo sapiens identified by UniProt accession Q96EA4, 605 residues long. MolForge cross-references it against 0 known binders and 226 disease associations.
- UniProt accession: Q96EA4; gene symbol SPDL1.
- Organism: Homo sapiens.
- Length: 605 amino acids.
- Top disease associations (Open Targets): sex hormone-binding globulin measurement, interstitial lung disease and non-melanoma skin carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein Spindly |
|---|---|
| UniProt accession | Q96EA4 |
| Gene | SPDL1 |
| Organism | Homo sapiens |
| Length | 605 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (226)
Diseases linked to this target (Open Targets).
- sex hormone-binding globulin measurement · score 0.49
- interstitial lung disease · score 0.44
- non-melanoma skin carcinoma · score 0.42
- skin cancer · score 0.42
- male reproductive organ cancer · score 0.41
- prostate carcinoma · score 0.40
- self reported educational attainment · score 0.36
- cancer · score 0.35
- pulmonary fibrosis · score 0.34
- prostate cancer · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96EA4-F1 | alphafold | PREDICTED | 74.29 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96EA4.
Amino-acid sequence (605 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPDL1?
The strongest Open Targets associations for SPDL1 are sex hormone-binding globulin measurement, interstitial lung disease, non-melanoma skin carcinoma, skin cancer and male reproductive organ cancer.
How long is the SPDL1 protein?
The Homo sapiens SPDL1 protein (UniProt Q96EA4) is 605 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96EA4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96EA4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.