THAP domain-containing protein 11 (THAP11)
Homo sapiens — UniProt Q96EK4
Data last refreshed: (UniProt release unknown)
Key facts
THAP domain-containing protein 11 (THAP11) is a protein from Homo sapiens identified by UniProt accession Q96EK4, 314 residues long. MolForge cross-references it against 0 known binders and 36 disease associations.
- UniProt accession: Q96EK4; gene symbol THAP11.
- Organism: Homo sapiens.
- Length: 314 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, methylmalonic acidemia with homocystinuria, type cblX and brain measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | THAP domain-containing protein 11 |
|---|---|
| UniProt accession | Q96EK4 |
| Gene | THAP11 |
| Organism | Homo sapiens |
| Length | 314 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (36)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- methylmalonic acidemia with homocystinuria, type cblX · score 0.27
- brain measurement · score 0.09
- mean corpuscular hemoglobin concentration · score 0.05
- Ataxia · score 0.04
- erythrocyte count · score 0.03
- stem Cell Factor measurement · score 0.03
- red blood cell density measurement · score 0.03
- physical activity · score 0.03
- HDL cholesterol change measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96EK4-F1 | alphafold | PREDICTED | 67.23 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96EK4.
Amino-acid sequence (314 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with THAP11?
The strongest Open Targets associations for THAP11 are neurodegenerative disease, methylmalonic acidemia with homocystinuria, type cblX, brain measurement, mean corpuscular hemoglobin concentration and Ataxia.
How long is the THAP11 protein?
The Homo sapiens THAP11 protein (UniProt Q96EK4) is 314 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96EK4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96EK4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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