E3 ubiquitin-protein ligase RNF125 (RNF125)
Homo sapiens — UniProt Q96EQ8
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase RNF125 (RNF125) is a protein from Homo sapiens identified by UniProt accession Q96EQ8, 232 residues long. MolForge cross-references it against 0 known binders and 68 disease associations.
- UniProt accession: Q96EQ8; gene symbol RNF125.
- Organism: Homo sapiens.
- Length: 232 amino acids.
- Top disease associations (Open Targets): Tenorio syndrome, Intellectual disability and TNF-related apoptosis-inducing ligand measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase RNF125 |
|---|---|
| UniProt accession | Q96EQ8 |
| Gene | RNF125 |
| Organism | Homo sapiens |
| Length | 232 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (68)
Diseases linked to this target (Open Targets).
- Tenorio syndrome · score 0.71
- Intellectual disability · score 0.37
- TNF-related apoptosis-inducing ligand measurement · score 0.35
- genetic disorder · score 0.18
- neoplasm · score 0.10
- hepatocellular carcinoma · score 0.09
- Crigler-Najjar syndrome type 2 · score 0.06
- melanoma · score 0.06
- maple syrup urine disease · score 0.06
- schizophrenia · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96EQ8-F1 | alphafold | PREDICTED | 77.38 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96EQ8.
Amino-acid sequence (232 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RNF125?
The strongest Open Targets associations for RNF125 are Tenorio syndrome, Intellectual disability, TNF-related apoptosis-inducing ligand measurement, genetic disorder and neoplasm.
How long is the RNF125 protein?
The Homo sapiens RNF125 protein (UniProt Q96EQ8) is 232 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96EQ8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96EQ8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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