p53 apoptosis effector related to PMP-22 (PERP)
Homo sapiens — UniProt Q96FX8
Data last refreshed: (UniProt release unknown)
Key facts
p53 apoptosis effector related to PMP-22 (PERP) is a protein from Homo sapiens identified by UniProt accession Q96FX8, 193 residues long. MolForge cross-references it against 0 known binders and 133 disease associations.
- UniProt accession: Q96FX8; gene symbol PERP.
- Organism: Homo sapiens.
- Length: 193 amino acids.
- Top disease associations (Open Targets): erythrokeratodermia variabilis et progressiva 7, Olmsted syndrome 1 and Olmsted syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | p53 apoptosis effector related to PMP-22 |
|---|---|
| UniProt accession | Q96FX8 |
| Gene | PERP |
| Organism | Homo sapiens |
| Length | 193 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (133)
Diseases linked to this target (Open Targets).
- erythrokeratodermia variabilis et progressiva 7 · score 0.56
- Olmsted syndrome 1 · score 0.47
- Olmsted syndrome · score 0.37
- breast adenocarcinoma · score 0.27
- gastric adenocarcinoma · score 0.25
- ichthyosis · score 0.23
- small cell lung carcinoma · score 0.21
- genetic disorder · score 0.18
- cutaneous melanoma · score 0.13
- hepatocellular carcinoma · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96FX8-F1 | alphafold | PREDICTED | 82.32 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96FX8.
Amino-acid sequence (193 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PERP?
The strongest Open Targets associations for PERP are erythrokeratodermia variabilis et progressiva 7, Olmsted syndrome 1, Olmsted syndrome, breast adenocarcinoma and gastric adenocarcinoma.
How long is the PERP protein?
The Homo sapiens PERP protein (UniProt Q96FX8) is 193 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96FX8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96FX8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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