Mediator of RNA polymerase II transcription subunit 8 (MED8)
Homo sapiens — UniProt Q96G25
Data last refreshed: (UniProt release unknown)
Key facts
Mediator of RNA polymerase II transcription subunit 8 (MED8) is a protein from Homo sapiens identified by UniProt accession Q96G25, 268 residues long. MolForge cross-references it against 0 known binders and 43 disease associations.
- UniProt accession: Q96G25; gene symbol MED8.
- Organism: Homo sapiens.
- Length: 268 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, breast adenocarcinoma and systolic blood pressure.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Mediator of RNA polymerase II transcription subunit 8 |
|---|---|
| UniProt accession | Q96G25 |
| Gene | MED8 |
| Organism | Homo sapiens |
| Length | 268 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (43)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- breast adenocarcinoma · score 0.11
- systolic blood pressure · score 0.09
- platelet count · score 0.09
- hepatocellular carcinoma · score 0.08
- diastolic blood pressure · score 0.07
- nonpapillary renal cell carcinoma · score 0.06
- neutrophil count · score 0.05
- leukocyte count · score 0.05
- IGF-1 measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96G25-F1 | alphafold | PREDICTED | 75.52 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96G25.
Amino-acid sequence (268 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MED8?
The strongest Open Targets associations for MED8 are neurodegenerative disease, breast adenocarcinoma, systolic blood pressure, platelet count and hepatocellular carcinoma.
How long is the MED8 protein?
The Homo sapiens MED8 protein (UniProt Q96G25) is 268 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96G25 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96G25 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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