Aurora kinase B (AURKB)

About Aurora kinase B

Aurora kinase B (AURKB) is a protein from Homo sapiens identified by UniProt accession Q96GD4, 344 residues long. MolForge cross-references it against 0 known binders and 342 disease associations.

Target properties

Protein name	Aurora kinase B
UniProt accession	Q96GD4
Gene	AURKB
Organism	Homo sapiens
Length	344 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (342)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.56
multiple sclerosis · score 0.53
lysosomal storage disease · score 0.53
Parkinson disease · score 0.53
Alzheimer disease · score 0.53
neuroinflammatory disorder · score 0.44
small cell lung carcinoma · score 0.31
acute myeloid leukemia · score 0.29
glioblastoma multiforme · score 0.27
breast adenocarcinoma · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96GD4-F1	alphafold	PREDICTED	78.82	—

Amino-acid sequence (344 residues)

MAQKENSYPW PYGRQTAPSG LSTLPQRVLR KEPVTPSALV LMSRSNVQPT AAPGQKVMEN SSGTPDILTR HFTIDDFEIG RPLGKGKFGN VYLAREKKSH FIVALKVLFK SQIEKEGVEH QLRREIEIQA HLHHPNILRL YNYFYDRRRI YLILEYAPRG ELYKELQKSC TFDEQRTATI MEELADALMY CHGKKVIHRD IKPENLLLGL KGELKIADFG WSVHAPSLRR KTMCGTLDYL PPEMIEGRMH NEKVDLWCIG VLCYELLVGN PPFESASHNE TYRRIVKVDL KFPASVPMGA QDLISKLLRH NPSERLPLAQ VSAHPWVRAN SRRVLPPSAL QSVA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards