tRNA (uracil-5-)-methyltransferase homolog B (TRMT2B)
Homo sapiens — UniProt Q96GJ1
Data last refreshed: (UniProt release unknown)
Key facts
tRNA (uracil-5-)-methyltransferase homolog B (TRMT2B) is a protein from Homo sapiens identified by UniProt accession Q96GJ1, 504 residues long. MolForge cross-references it against 0 known binders and 6 disease associations.
- UniProt accession: Q96GJ1; gene symbol TRMT2B.
- Organism: Homo sapiens.
- Length: 504 amino acids.
- Top disease associations (Open Targets): juvenile amyotrophic lateral sclerosis, axial length measurement and Amyotrophic lateral sclerosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | tRNA (uracil-5-)-methyltransferase homolog B |
|---|---|
| UniProt accession | Q96GJ1 |
| Gene | TRMT2B |
| Organism | Homo sapiens |
| Length | 504 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (6)
Diseases linked to this target (Open Targets).
- juvenile amyotrophic lateral sclerosis · score 0.01
- axial length measurement · score 0.01
- Amyotrophic lateral sclerosis · score 0.01
- congenital heart disease · score 0.00
- cancer · score 0.00
- non-small cell lung carcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96GJ1-F1 | alphafold | PREDICTED | 82.58 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96GJ1.
Amino-acid sequence (504 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TRMT2B?
The strongest Open Targets associations for TRMT2B are juvenile amyotrophic lateral sclerosis, axial length measurement, Amyotrophic lateral sclerosis, congenital heart disease and cancer.
How long is the TRMT2B protein?
The Homo sapiens TRMT2B protein (UniProt Q96GJ1) is 504 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96GJ1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96GJ1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.