SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1)
Homo sapiens — UniProt Q96GM5
Data last refreshed: (UniProt release unknown)
Key facts
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) is a protein from Homo sapiens identified by UniProt accession Q96GM5, 515 residues long. MolForge cross-references it against 0 known binders and 161 disease associations.
- UniProt accession: Q96GM5; gene symbol SMARCD1.
- Organism: Homo sapiens.
- Length: 515 amino acids.
- Top disease associations (Open Targets): Coffin-Siris syndrome 11, Global developmental delay and Intellectual disability.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 |
|---|---|
| UniProt accession | Q96GM5 |
| Gene | SMARCD1 |
| Organism | Homo sapiens |
| Length | 515 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (161)
Diseases linked to this target (Open Targets).
- Coffin-Siris syndrome 11 · score 0.70
- Global developmental delay · score 0.53
- Intellectual disability · score 0.46
- Abnormal foot morphology · score 0.46
- syndromic intellectual disability · score 0.46
- Feeding difficulties · score 0.46
- Generalized hypotonia · score 0.46
- Coffin-Siris syndrome · score 0.37
- breast adenocarcinoma · score 0.27
- alopecia, androgenetic, 1 · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96GM5-F1 | alphafold | PREDICTED | 76.52 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96GM5.
Amino-acid sequence (515 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMARCD1?
The strongest Open Targets associations for SMARCD1 are Coffin-Siris syndrome 11, Global developmental delay, Intellectual disability, Abnormal foot morphology and syndromic intellectual disability.
How long is the SMARCD1 protein?
The Homo sapiens SMARCD1 protein (UniProt Q96GM5) is 515 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96GM5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96GM5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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