Target of EGR1 protein 1 (TOE1)
Homo sapiens — UniProt Q96GM8
Data last refreshed: (UniProt release unknown)
Key facts
Target of EGR1 protein 1 (TOE1) is a protein from Homo sapiens identified by UniProt accession Q96GM8, 510 residues long. MolForge cross-references it against 0 known binders and 40 disease associations.
- UniProt accession: Q96GM8; gene symbol TOE1.
- Organism: Homo sapiens.
- Length: 510 amino acids.
- Top disease associations (Open Targets): pontocerebellar hypoplasia type 7, neurodegenerative disease and mutyh-associated polyposis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Target of EGR1 protein 1 |
|---|---|
| UniProt accession | Q96GM8 |
| Gene | TOE1 |
| Organism | Homo sapiens |
| Length | 510 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (40)
Diseases linked to this target (Open Targets).
- pontocerebellar hypoplasia type 7 · score 0.80
- neurodegenerative disease · score 0.54
- mutyh-associated polyposis · score 0.53
- familial adenomatous polyposis 2 · score 0.53
- Familial adenomatous polyposis · score 0.53
- Inherited cancer-predisposing syndrome · score 0.48
- hereditary neoplastic syndrome · score 0.48
- pontocerebellar hypoplasia · score 0.46
- gastric cancer · score 0.46
- genetic disorder · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96GM8-F1 | alphafold | PREDICTED | 77.75 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96GM8.
Amino-acid sequence (510 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TOE1?
The strongest Open Targets associations for TOE1 are pontocerebellar hypoplasia type 7, neurodegenerative disease, mutyh-associated polyposis, familial adenomatous polyposis 2 and Familial adenomatous polyposis.
How long is the TOE1 protein?
The Homo sapiens TOE1 protein (UniProt Q96GM8) is 510 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96GM8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96GM8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.