Methionine--tRNA ligase, mitochondrial (MARS2)
Homo sapiens — UniProt Q96GW9
Data last refreshed: (UniProt release unknown)
Key facts
Methionine--tRNA ligase, mitochondrial (MARS2) is a protein from Homo sapiens identified by UniProt accession Q96GW9, 593 residues long. MolForge cross-references it against 0 known binders and 74 disease associations.
- UniProt accession: Q96GW9; gene symbol MARS2.
- Organism: Homo sapiens.
- Length: 593 amino acids.
- Top disease associations (Open Targets): spastic ataxia 3, Autosomal recessive spastic ataxia with leukoencephalopathy and Combined oxidative phosphorylation defect type 25.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Methionine--tRNA ligase, mitochondrial |
|---|---|
| UniProt accession | Q96GW9 |
| Gene | MARS2 |
| Organism | Homo sapiens |
| Length | 593 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (74)
Diseases linked to this target (Open Targets).
- spastic ataxia 3 · score 0.71
- Autosomal recessive spastic ataxia with leukoencephalopathy · score 0.70
- Combined oxidative phosphorylation defect type 25 · score 0.56
- neurodegenerative disease · score 0.54
- mitochondrial oxidative phosphorylation disorder · score 0.47
- autosomal recessive spastic ataxia · score 0.46
- combined oxidative phosphorylation defect type 25 · score 0.46
- mitochondrial disease · score 0.37
- autosomal recessive limb-girdle muscular dystrophy · score 0.27
- lysosomal storage disease · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96GW9-F1 | alphafold | PREDICTED | 89.32 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96GW9.
Amino-acid sequence (593 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MARS2?
The strongest Open Targets associations for MARS2 are spastic ataxia 3, Autosomal recessive spastic ataxia with leukoencephalopathy, Combined oxidative phosphorylation defect type 25, neurodegenerative disease and mitochondrial oxidative phosphorylation disorder.
How long is the MARS2 protein?
The Homo sapiens MARS2 protein (UniProt Q96GW9) is 593 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96GW9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96GW9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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