Tectonic-2 (TCTN2)
Homo sapiens — UniProt Q96GX1
Data last refreshed: (UniProt release unknown)
Key facts
Tectonic-2 (TCTN2) is a protein from Homo sapiens identified by UniProt accession Q96GX1, 697 residues long. MolForge cross-references it against 0 known binders and 68 disease associations.
- UniProt accession: Q96GX1; gene symbol TCTN2.
- Organism: Homo sapiens.
- Length: 697 amino acids.
- Top disease associations (Open Targets): Joubert syndrome, Meckel syndrome and Joubert syndrome and related disorders.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Tectonic-2 |
|---|---|
| UniProt accession | Q96GX1 |
| Gene | TCTN2 |
| Organism | Homo sapiens |
| Length | 697 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (68)
Diseases linked to this target (Open Targets).
- Joubert syndrome · score 0.76
- Meckel syndrome · score 0.73
- Joubert syndrome and related disorders · score 0.68
- low density lipoprotein cholesterol measurement · score 0.25
- genetic disorder · score 0.19
- body fat percentage · score 0.15
- Microcephaly · score 0.11
- cancer · score 0.07
- FEV/FVC ratio · score 0.07
- leukocyte count · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96GX1-F1 | alphafold | PREDICTED | 74.47 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96GX1.
Amino-acid sequence (697 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TCTN2?
The strongest Open Targets associations for TCTN2 are Joubert syndrome, Meckel syndrome, Joubert syndrome and related disorders, low density lipoprotein cholesterol measurement and genetic disorder.
How long is the TCTN2 protein?
The Homo sapiens TCTN2 protein (UniProt Q96GX1) is 697 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96GX1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96GX1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.