Serine/threonine-protein kinase greatwall (MASTL)
Homo sapiens — UniProt Q96GX5
Data last refreshed: (UniProt release unknown)
Key facts
Serine/threonine-protein kinase greatwall (MASTL) is a protein from Homo sapiens identified by UniProt accession Q96GX5, 879 residues long. MolForge cross-references it against 0 known binders and 65 disease associations.
- UniProt accession: Q96GX5; gene symbol MASTL.
- Organism: Homo sapiens.
- Length: 879 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, multiple sclerosis and Parkinson disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Serine/threonine-protein kinase greatwall |
|---|---|
| UniProt accession | Q96GX5 |
| Gene | MASTL |
| Organism | Homo sapiens |
| Length | 879 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (65)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- multiple sclerosis · score 0.50
- Parkinson disease · score 0.50
- Alzheimer disease · score 0.50
- lysosomal storage disease · score 0.50
- autosomal thrombocytopenia with normal platelets · score 0.37
- platelet count · score 0.26
- Thrombocytopenia · score 0.24
- platelet crit · score 0.21
- severe aplastic anemia · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96GX5-F1 | alphafold | PREDICTED | 54.19 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96GX5.
Amino-acid sequence (879 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MASTL?
The strongest Open Targets associations for MASTL are neurodegenerative disease, multiple sclerosis, Parkinson disease, Alzheimer disease and lysosomal storage disease.
How long is the MASTL protein?
The Homo sapiens MASTL protein (UniProt Q96GX5) is 879 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96GX5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96GX5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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