Centromere protein N (CENPN)

About Centromere protein N

Centromere protein N (CENPN) is a protein from Homo sapiens identified by UniProt accession Q96H22, 339 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.

Target properties

Protein name	Centromere protein N
UniProt accession	Q96H22
Gene	CENPN
Organism	Homo sapiens
Length	339 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (47)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.33
mean corpuscular volume · score 0.24
cystatin C measurement · score 0.21
mean reticulocyte volume · score 0.20
serum urea measurement · score 0.19
mosaic loss of chromosome Y measurement · score 0.18
heel bone mineral density · score 0.13
mean corpuscular hemoglobin concentration · score 0.11
medulloblastoma · score 0.10
blood urea nitrogen measurement · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96H22-F1	alphafold	PREDICTED	85.59	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96H22.

Amino-acid sequence (339 residues)

MDETVAEFIK RTILKIPMNE LTTILKAWDF LSENQLQTVN FRQRKESVVQ HLIHLCEEKR ASISDAALLD IIYMQFHQHQ KVWEVFQMSK GPGEDVDLFD MKQFKNSFKK ILQRALKNVT VSFRETEENA VWIRIAWGTQ YTKPNQYKPT YVVYYSQTPY AFTSSSMLRR NTPLLGQALT IASKHHQIVK MDLRSRYLDS LKAIVFKQYN QTFETHNSTT PLQERSLGLD INMDSRIIHE NIVEKERVQR ITQETFGDYP QPQLEFAQYK LETKFKSGLN GSILAEREEP LRCLIKFSSP HLLEALKSLA PAGIADAPLS PLLTCIPNKR MNYFKIRDK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards