Transmembrane protein 80 (TMEM80)

About Transmembrane protein 80

Transmembrane protein 80 (TMEM80) is a protein from Homo sapiens identified by UniProt accession Q96HE8, 143 residues long. MolForge cross-references it against 0 known binders and 12 disease associations.

Target properties

Protein name	Transmembrane protein 80
UniProt accession	Q96HE8
Gene	TMEM80
Organism	Homo sapiens
Length	143 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (12)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.23
body height · score 0.16
blood protein measurement · score 0.06
adolescent idiopathic scoliosis · score 0.03
metabolite measurement · score 0.02
ciliopathy · score 0.01
Systemic lupus erythematosus · score 0.00
adrenal cortex carcinoma · score 0.00
Joubert syndrome with orofaciodigital defect · score 0.00
Joubert syndrome · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96HE8-F1	alphafold	PREDICTED	84.27	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96HE8.

Amino-acid sequence (143 residues)

MAAPRRGRGS STVLSSVPLQ MLFYLSGTYY ALYFLATLLM ITYKSQVFSY PHRYLVLDLA LLFLMGILEA VRLYLGTRGN LTEAERPLAA SLALTAGTAL LSAHFLLWQA LVLWADWALS ATLLALHGLE AVLQVVAIAA FTR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards