Secreted frizzled-related protein 2 (SFRP2)
Homo sapiens — UniProt Q96HF1
Data last refreshed: (UniProt release unknown)
Key facts
Secreted frizzled-related protein 2 (SFRP2) is a protein from Homo sapiens identified by UniProt accession Q96HF1, 295 residues long. MolForge cross-references it against 0 known binders and 627 disease associations.
- UniProt accession: Q96HF1; gene symbol SFRP2.
- Organism: Homo sapiens.
- Length: 295 amino acids.
- Top disease associations (Open Targets): facial morphology measurement, nose morphology measurement and FEV/FVC ratio.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Secreted frizzled-related protein 2 |
|---|---|
| UniProt accession | Q96HF1 |
| Gene | SFRP2 |
| Organism | Homo sapiens |
| Length | 295 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (627)
Diseases linked to this target (Open Targets).
- facial morphology measurement · score 0.42
- nose morphology measurement · score 0.42
- FEV/FVC ratio · score 0.38
- grip strength measurement · score 0.34
- cortical surface area measurement · score 0.33
- brain measurement · score 0.28
- C-reactive protein measurement · score 0.26
- neuroimaging measurement · score 0.25
- pulse wave reflection index measurement · score 0.24
- DNA methylation · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96HF1-F1 | alphafold | PREDICTED | 82.12 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96HF1.
Amino-acid sequence (295 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SFRP2?
The strongest Open Targets associations for SFRP2 are facial morphology measurement, nose morphology measurement, FEV/FVC ratio, grip strength measurement and cortical surface area measurement.
How long is the SFRP2 protein?
The Homo sapiens SFRP2 protein (UniProt Q96HF1) is 295 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96HF1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96HF1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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