Sentrin-specific protease 5 (SENP5)
Homo sapiens — UniProt Q96HI0
Data last refreshed: (UniProt release unknown)
Key facts
Sentrin-specific protease 5 (SENP5) is a protein from Homo sapiens identified by UniProt accession Q96HI0, 755 residues long. MolForge cross-references it against 0 known binders and 43 disease associations.
- UniProt accession: Q96HI0; gene symbol SENP5.
- Organism: Homo sapiens.
- Length: 755 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, endometrial cancer and low grade glioma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sentrin-specific protease 5 |
|---|---|
| UniProt accession | Q96HI0 |
| Gene | SENP5 |
| Organism | Homo sapiens |
| Length | 755 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (43)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.26
- endometrial cancer · score 0.18
- low grade glioma · score 0.18
- breast adenocarcinoma · score 0.18
- glioblastoma multiforme · score 0.15
- genetic disorder · score 0.12
- platelet count · score 0.07
- eosinophil count · score 0.06
- sum of eosinophil and basophil counts · score 0.06
- lymphocyte count · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96HI0-F1 | alphafold | PREDICTED | 54.94 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96HI0.
Amino-acid sequence (755 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SENP5?
The strongest Open Targets associations for SENP5 are neurodegenerative disease, endometrial cancer, low grade glioma, breast adenocarcinoma and glioblastoma multiforme.
How long is the SENP5 protein?
The Homo sapiens SENP5 protein (UniProt Q96HI0) is 755 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96HI0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96HI0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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