Membrane-spanning 4-domains subfamily A member 3 (MS4A3)
Homo sapiens — UniProt Q96HJ5
Data last refreshed: (UniProt release unknown)
Key facts
Membrane-spanning 4-domains subfamily A member 3 (MS4A3) is a protein from Homo sapiens identified by UniProt accession Q96HJ5, 214 residues long. MolForge cross-references it against 0 known binders and 36 disease associations.
- UniProt accession: Q96HJ5; gene symbol MS4A3.
- Organism: Homo sapiens.
- Length: 214 amino acids.
- Top disease associations (Open Targets): leukocyte count, neutrophil count and myeloid white cell count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Membrane-spanning 4-domains subfamily A member 3 |
|---|---|
| UniProt accession | Q96HJ5 |
| Gene | MS4A3 |
| Organism | Homo sapiens |
| Length | 214 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (36)
Diseases linked to this target (Open Targets).
- leukocyte count · score 0.27
- neutrophil count · score 0.18
- myeloid white cell count · score 0.11
- vitamin B12 measurement · score 0.09
- osteosarcoma · score 0.06
- neoplasm · score 0.04
- chronic myelogenous leukemia · score 0.02
- carpal tunnel syndrome · score 0.02
- psoriatic arthritis · score 0.02
- acute myeloid leukemia · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96HJ5-F1 | alphafold | PREDICTED | 78.09 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96HJ5.
Amino-acid sequence (214 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MS4A3?
The strongest Open Targets associations for MS4A3 are leukocyte count, neutrophil count, myeloid white cell count, vitamin B12 measurement and osteosarcoma.
How long is the MS4A3 protein?
The Homo sapiens MS4A3 protein (UniProt Q96HJ5) is 214 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96HJ5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96HJ5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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