Dedicator of cytokinesis protein 6 (DOCK6)

Homo sapiens — UniProt Q96HP0

Gene: DOCK6Homo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

Dedicator of cytokinesis protein 6 (DOCK6) is a protein from Homo sapiens identified by UniProt accession Q96HP0, 2047 residues long. MolForge cross-references it against 0 known binders and 136 disease associations.

UniProt accession: Q96HP0; gene symbol DOCK6.
Organism: Homo sapiens.
Length: 2047 amino acids.
Top disease associations (Open Targets): Adams-Oliver syndrome, genetic disorder and hypercholanemia, familial 1.
3D structure: AlphaFold model available.

Target properties

Protein name	Dedicator of cytokinesis protein 6
UniProt accession	Q96HP0
Gene	DOCK6
Organism	Homo sapiens
Length	2047 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (136)

Diseases linked to this target (Open Targets).

Adams-Oliver syndrome · score 0.79
genetic disorder · score 0.49
hypercholanemia, familial 1 · score 0.26
osteitis deformans · score 0.26
high density lipoprotein cholesterol measurement · score 0.25
total cholesterol measurement · score 0.24
Alzheimer disease · score 0.21
multiple sclerosis · score 0.21
neurodegenerative disease · score 0.21
lysosomal storage disease · score 0.21

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96HP0-F1	alphafold	PREDICTED	77.09	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96HP0.

Amino-acid sequence (2047 residues)

MAASERRAFA HKINRTVAAE VRKQVSRERS GSPHSSRRCS SSLGVPLTEV VEPLDFEDVL LSRPPDAEPG PLRDLVEFPA DDLELLLQPR ECRTTEPGIP KDEKLDAQVR AAVEMYIEDW VIVHRRYQYL SAAYSPVTTD TQRERQKGLP RQVFEQDASG DERSGPEDSN DSRRGSGSPE DTPRSSGASS IFDLRNLAAD SLLPSLLERA APEDVDRRNE TLRRQHRPPA LLTLYPAPDE DEAVERCSRP EPPREHFGQR ILVKCLSLKF EIEIEPIFGI LALYDVREKK KISENFYFDL NSDSMKGLLR AHGTHPAIST LARSAIFSVT YPSPDIFLVI KLEKVLQQGD ISECCEPYMV LKEVDTAKNK EKLEKLRLAA EQFCTRLGRY RMPFAWTAVH LANIVSSAGQ LDRDSDSEGE RRPAWTDRRR RGPQDRASSG DDACSFSGFR PATLTVTNFF KQEAERLSDE DLFKFLADMR RPSSLLRRLR PVTAQLKIDI SPAPENPHFC LSPELLHIKP YPDPRGRPTK EILEFPAREV YAPHTSYRNL LYVYPHSLNF SSRQGSVRNL AVRVQYMTGE DPSQALPVIF GKSSCSEFTR EAFTPVVYHN KSPEFYEEFK LHLPACVTEN HHLLFTFYHV SCQPRPGTAL ETPVGFTWIP LLQHGRLRTG PFCLPVSVDQ PPPSYSVLTP DVALPGMRWV DGHKGVFSVE LTAVSSVHPQ DPYLDKFFTL VHVLEEGAFP FRLKDTVLSE GNVEQELRAS LAALRLASPE PLVAFSHHVL DKLVRLVIRP PIISGQIVNL GRGAFEAMAH VVSLVHRSLE AAQDARGHCP QLAAYVHYAF RLPGTEPSLP DGAPPVTVQA ATLARGSGRP ASLYLARSKS ISSSNPDLAV APGSVDDEVS RILASKLLHE ELALQWVVSS SAVREAILQH AWFFFQLMVK SMALHLLLGQ RLDTPRKLRF PGRFLDDITA LVGSVGLEVI TRVHKDVELA EHLNASLAFF LSDLLSLVDR GFVFSLVRAH YKQVATRLQS SPNPAALLTL RMEFTRILCS HEHYVTLNLP CCPLSPPASP SPSVSSTTSQ SSTFSSQAPD PKVTSMFELS GPFRQQHFLA GLLLTELALA LEPEAEGAFL LHKKAISAVH SLLCGHDTDP RYAEATVKAR VAELYLPLLS IARDTLPRLH DFAEGPGQRS RLASMLDSDT EGEGDIAGTI NPSVAMAIAG GPLAPGSRAS ISQGPPTASR AGCALSAESS RTLLACVLWV LKNTEPALLQ RWATDLTLPQ LGRLLDLLYL CLAAFEYKGK KAFERINSLT FKKSLDMKAR LEEAILGTIG ARQEMVRRSR ERSPFGNPEN VRWRKSVTHW KQTSDRVDKT KDEMEHEALV EGNLATEASL VVLDTLEIIV QTVMLSEARE SVLGAVLKVV LYSLGSAQSA LFLQHGLATQ RALVSKFPEL LFEEDTELCA DLCLRLLRHC GSRISTIRTH ASASLYLLMR QNFEIGHNFA RVKMQVTMSL SSLVGTTQNF SEEHLRRSLK TILTYAEEDM GLRDSTFAEQ VQDLMFNLHM ILTDTVKMKE HQEDPEMLID LMYRIARGYQ GSPDLRLTWL QNMAGKHAEL GNHAEAAQCM VHAAALVAEY LALLEDHRHL PVGCVSFQNI SSNVLEESAI SDDILSPDEE GFCSGKHFTE LGLVGLLEQA AGYFTMGGLY EAVNEVYKNL IPILEAHRDY KKLAAVHGKL QEAFTKIMHQ SSGWERVFGT YFRVGFYGAH FGDLDEQEFV YKEPSITKLA EISHRLEEFY TERFGDDVVE IIKDSNPVDK SKLDSQKAYI QITYVEPYFD TYELKDRVTY FDRNYGLRTF LFCTPFTPDG RAHGELPEQH KRKTLLSTDH AFPYIKTRIR VCHREETVLT PVEVAIEDMQ KKTRELAFAT EQDPPDAKML QMVLQGSVGP TVNQGPLEVA QVFLAEIPED PKLFRHHNKL RLCFKDFCKK CEDALRKNKA LIGPDQKEYH RELERNYCRL REALQPLLTQ RLPQLMAPTP PGLRNSLNRA SFRKADL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with DOCK6?

The strongest Open Targets associations for DOCK6 are Adams-Oliver syndrome, genetic disorder, hypercholanemia, familial 1, osteitis deformans and high density lipoprotein cholesterol measurement.

How long is the DOCK6 protein?

The Homo sapiens DOCK6 protein (UniProt Q96HP0) is 2047 amino acids long.

Browse: Targets: D · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q96HP0 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q96HP0 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

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