Small G protein signaling modulator 3 (SGSM3)
Homo sapiens — UniProt Q96HU1
Data last refreshed: (UniProt release unknown)
Key facts
Small G protein signaling modulator 3 (SGSM3) is a protein from Homo sapiens identified by UniProt accession Q96HU1, 749 residues long. MolForge cross-references it against 0 known binders and 59 disease associations.
- UniProt accession: Q96HU1; gene symbol SGSM3.
- Organism: Homo sapiens.
- Length: 749 amino acids.
- Top disease associations (Open Targets): glomerular filtration rate, creatinine measurement and Neurodevelopmental disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Small G protein signaling modulator 3 |
|---|---|
| UniProt accession | Q96HU1 |
| Gene | SGSM3 |
| Organism | Homo sapiens |
| Length | 749 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (59)
Diseases linked to this target (Open Targets).
- glomerular filtration rate · score 0.27
- creatinine measurement · score 0.25
- Neurodevelopmental disorder · score 0.18
- Intellectual disability · score 0.18
- mammographic density measurement · score 0.11
- dense area measurement · score 0.11
- breast carcinoma · score 0.11
- pulse pressure measurement · score 0.10
- lymphocyte count · score 0.09
- attention deficit hyperactivity disorder · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96HU1-F1 | alphafold | PREDICTED | 82.63 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96HU1.
Amino-acid sequence (749 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SGSM3?
The strongest Open Targets associations for SGSM3 are glomerular filtration rate, creatinine measurement, Neurodevelopmental disorder, Intellectual disability and mammographic density measurement.
How long is the SGSM3 protein?
The Homo sapiens SGSM3 protein (UniProt Q96HU1) is 749 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96HU1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96HU1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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