GTP-binding protein Di-Ras2 (DIRAS2)
Homo sapiens — UniProt Q96HU8
Data last refreshed: (UniProt release unknown)
Key facts
GTP-binding protein Di-Ras2 (DIRAS2) is a protein from Homo sapiens identified by UniProt accession Q96HU8, 199 residues long. MolForge cross-references it against 0 known binders and 59 disease associations.
- UniProt accession: Q96HU8; gene symbol DIRAS2.
- Organism: Homo sapiens.
- Length: 199 amino acids.
- Top disease associations (Open Targets): age-related hearing impairment, PHF-tau measurement and type 1 diabetes mellitus.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | GTP-binding protein Di-Ras2 |
|---|---|
| UniProt accession | Q96HU8 |
| Gene | DIRAS2 |
| Organism | Homo sapiens |
| Length | 199 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (59)
Diseases linked to this target (Open Targets).
- age-related hearing impairment · score 0.29
- PHF-tau measurement · score 0.29
- type 1 diabetes mellitus · score 0.23
- adolescent idiopathic scoliosis · score 0.17
- platelet count · score 0.10
- sleep measurement · score 0.07
- neoplasm · score 0.06
- platelet crit · score 0.06
- platelet component distribution width · score 0.05
- monocyte count · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96HU8-F1 | alphafold | PREDICTED | 88.82 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96HU8.
Amino-acid sequence (199 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DIRAS2?
The strongest Open Targets associations for DIRAS2 are age-related hearing impairment, PHF-tau measurement, type 1 diabetes mellitus, adolescent idiopathic scoliosis and platelet count.
How long is the DIRAS2 protein?
The Homo sapiens DIRAS2 protein (UniProt Q96HU8) is 199 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96HU8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96HU8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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