DDRGK domain-containing protein 1 (DDRGK1)
Homo sapiens — UniProt Q96HY6
Data last refreshed: (UniProt release unknown)
Key facts
DDRGK domain-containing protein 1 (DDRGK1) is a protein from Homo sapiens identified by UniProt accession Q96HY6, 314 residues long. MolForge cross-references it against 0 known binders and 71 disease associations.
- UniProt accession: Q96HY6; gene symbol DDRGK1.
- Organism: Homo sapiens.
- Length: 314 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, spondyloepimetaphyseal dysplasia, Shohat type and serum gamma-glutamyl transferase measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DDRGK domain-containing protein 1 |
|---|---|
| UniProt accession | Q96HY6 |
| Gene | DDRGK1 |
| Organism | Homo sapiens |
| Length | 314 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (71)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- spondyloepimetaphyseal dysplasia, Shohat type · score 0.52
- serum gamma-glutamyl transferase measurement · score 0.27
- alkaline phosphatase measurement · score 0.23
- genetic disorder · score 0.19
- chronic hepatitis C virus infection · score 0.16
- Parkinson disease · score 0.10
- risk-taking behaviour · score 0.09
- non-alcoholic fatty liver disease · score 0.08
- rheumatic disease · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96HY6-F1 | alphafold | PREDICTED | 74.58 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96HY6.
Amino-acid sequence (314 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DDRGK1?
The strongest Open Targets associations for DDRGK1 are neurodegenerative disease, spondyloepimetaphyseal dysplasia, Shohat type, serum gamma-glutamyl transferase measurement, alkaline phosphatase measurement and genetic disorder.
How long is the DDRGK1 protein?
The Homo sapiens DDRGK1 protein (UniProt Q96HY6) is 314 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96HY6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96HY6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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