2-oxoadipate dehydrogenase complex component E1 (DHTKD1)
Homo sapiens — UniProt Q96HY7
Data last refreshed: (UniProt release unknown)
Key facts
2-oxoadipate dehydrogenase complex component E1 (DHTKD1) is a protein from Homo sapiens identified by UniProt accession Q96HY7, 919 residues long. MolForge cross-references it against 0 known binders and 229 disease associations.
- UniProt accession: Q96HY7; gene symbol DHTKD1.
- Organism: Homo sapiens.
- Length: 919 amino acids.
- Top disease associations (Open Targets): 2-aminoadipic 2-oxoadipic aciduria, Charcot-Marie-Tooth disease axonal type 2Q and Autosomal dominant Charcot-Marie-Tooth disease type 2Q.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | 2-oxoadipate dehydrogenase complex component E1 |
|---|---|
| UniProt accession | Q96HY7 |
| Gene | DHTKD1 |
| Organism | Homo sapiens |
| Length | 919 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (229)
Diseases linked to this target (Open Targets).
- 2-aminoadipic 2-oxoadipic aciduria · score 0.83
- Charcot-Marie-Tooth disease axonal type 2Q · score 0.58
- Autosomal dominant Charcot-Marie-Tooth disease type 2Q · score 0.50
- genetic disorder · score 0.50
- neurodegenerative disease · score 0.37
- protein measurement · score 0.35
- Tip-toe gait · score 0.34
- urinary metabolite measurement · score 0.30
- Charcot-Marie-Tooth disease type 2A2 · score 0.16
- Autosomal dominant Charcot-Marie-Tooth disease type 2A2 · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96HY7-F1 | alphafold | PREDICTED | 95.06 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96HY7.
Amino-acid sequence (919 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DHTKD1?
The strongest Open Targets associations for DHTKD1 are 2-aminoadipic 2-oxoadipic aciduria, Charcot-Marie-Tooth disease axonal type 2Q, Autosomal dominant Charcot-Marie-Tooth disease type 2Q, genetic disorder and neurodegenerative disease.
How long is the DHTKD1 protein?
The Homo sapiens DHTKD1 protein (UniProt Q96HY7) is 919 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96HY7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96HY7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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