Transcription cofactor HES-6 (HES6)
Homo sapiens — UniProt Q96HZ4
Data last refreshed: (UniProt release unknown)
Key facts
Transcription cofactor HES-6 (HES6) is a protein from Homo sapiens identified by UniProt accession Q96HZ4, 224 residues long. MolForge cross-references it against 0 known binders and 74 disease associations.
- UniProt accession: Q96HZ4; gene symbol HES6.
- Organism: Homo sapiens.
- Length: 224 amino acids.
- Top disease associations (Open Targets): chronotype measurement, gut microbiome measurement and mean corpuscular hemoglobin concentration.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transcription cofactor HES-6 |
|---|---|
| UniProt accession | Q96HZ4 |
| Gene | HES6 |
| Organism | Homo sapiens |
| Length | 224 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (74)
Diseases linked to this target (Open Targets).
- chronotype measurement · score 0.21
- gut microbiome measurement · score 0.16
- mean corpuscular hemoglobin concentration · score 0.08
- Red cell distribution width · score 0.08
- cancer · score 0.07
- hepatocellular carcinoma · score 0.07
- coronary artery disease · score 0.05
- neoplasm · score 0.05
- phospholipid measurement · score 0.05
- hemoglobin A1 measurement · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96HZ4-F1 | alphafold | PREDICTED | 70.29 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96HZ4.
Amino-acid sequence (224 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HES6?
The strongest Open Targets associations for HES6 are chronotype measurement, gut microbiome measurement, mean corpuscular hemoglobin concentration, Red cell distribution width and cancer.
How long is the HES6 protein?
The Homo sapiens HES6 protein (UniProt Q96HZ4) is 224 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96HZ4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96HZ4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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