About Asparaginyl-tRNA synthetase
Asparaginyl-tRNA synthetase (NARS2) is a protein
from Homo sapiens identified by UniProt accession
Q96I59, 477 residues long.
MolForge cross-references it against 0 known binders and
113 disease associations.
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
Disease associations (113)
Diseases linked to this target (Open Targets).
- Combined oxidative phosphorylation defect type 24 · score 0.79
- mitochondrial oxidative phosphorylation disorder · score 0.54
- neurodegenerative disease · score 0.50
- hearing loss, autosomal recessive · score 0.48
- DEND syndrome · score 0.37
- hepatoencephalopathy due to combined oxidative phosphorylation defect type 1 · score 0.37
- Hepatoencephalopathy due to combined oxidative phosphorylation deficiency type 1 · score 0.37
- Seizure · score 0.37
- erythrocyte count · score 0.37
- mitochondrial disease · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
Experimental structures are not indexed in MolForge yet —
search RCSB PDB for Q96I59.
Amino-acid sequence (477 residues)
MLGVRCLLRS VRFCSSAPFP KHKPSAKLSV RDALGAQNAS GERIKIQGWI RSVRSQKEVL FLHVNDGSSL ESLQVVADSG LDSRELNFGS SVEVQGQLIK SPSKRQNVEL KAEKIKVIGN CDAKDFPIKY KERHPLEYLR QYPHFRCRTN VLGSILRIRS EATAAIHSFF KDSGFVHIHT PIITSNDSEG AGELFQLEPS GKLKVPEENF FNVPAFLTVS GQLHLEVMSG AFTQVFTFGP TFRAENSQSR RHLAEFYMIE AEISFVDSLQ DLMQVIEELF KATTMMVLSK CPEDVELCHK FIAPGQKDRL EHMLKNNFLI ISYTEAVEIL KQASQNFTFT PEWGADLRTE HEKYLVKHCG NIPVFVINYP LTLKPFYMRD NEDGPQHTVA AVDLLVPGVG ELFGGGLREE RYHFLEERLA RSGLTEVYQW YLDLRRFGSV PHGGFGMGFE RYLQCILGVD NIKDVIPFPR FPHSCLL
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