Mannose-1-phosphate guanylyltransferase regulatory subunit alpha (GMPPA)
Homo sapiens — UniProt Q96IJ6
Data last refreshed: (UniProt release unknown)
Key facts
Mannose-1-phosphate guanylyltransferase regulatory subunit alpha (GMPPA) is a protein from Homo sapiens identified by UniProt accession Q96IJ6, 420 residues long. MolForge cross-references it against 0 known binders and 220 disease associations.
- UniProt accession: Q96IJ6; gene symbol GMPPA.
- Organism: Homo sapiens.
- Length: 420 amino acids.
- Top disease associations (Open Targets): Triple A syndrome, Global developmental delay and gastroesophageal reflux disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Mannose-1-phosphate guanylyltransferase regulatory subunit alpha |
|---|---|
| UniProt accession | Q96IJ6 |
| Gene | GMPPA |
| Organism | Homo sapiens |
| Length | 420 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (220)
Diseases linked to this target (Open Targets).
- Triple A syndrome · score 0.79
- Global developmental delay · score 0.34
- gastroesophageal reflux disease · score 0.34
- genetic disorder · score 0.19
- cognitive function measurement · score 0.13
- diet measurement · score 0.12
- glomerular filtration rate · score 0.11
- creatinine measurement · score 0.09
- self reported educational attainment · score 0.08
- neoplasm · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96IJ6-F1 | alphafold | PREDICTED | 93.05 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96IJ6.
Amino-acid sequence (420 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GMPPA?
The strongest Open Targets associations for GMPPA are Triple A syndrome, Global developmental delay, gastroesophageal reflux disease, genetic disorder and cognitive function measurement.
How long is the GMPPA protein?
The Homo sapiens GMPPA protein (UniProt Q96IJ6) is 420 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96IJ6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96IJ6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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