Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (NGLY1)
Homo sapiens — UniProt Q96IV0
Data last refreshed: (UniProt release unknown)
Key facts
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (NGLY1) is a protein from Homo sapiens identified by UniProt accession Q96IV0, 654 residues long. MolForge cross-references it against 1 known binders and 125 disease associations.
- UniProt accession: Q96IV0; gene symbol NGLY1.
- Organism: Homo sapiens.
- Length: 654 amino acids.
- Top disease associations (Open Targets): congenital disorder of deglycosylation, congenital disorder of deglycosylation 1 and Alacrimia-choreoathetosis-liver dysfunction syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase |
|---|---|
| UniProt accession | Q96IV0 |
| Gene | NGLY1 |
| Organism | Homo sapiens |
| Length | 654 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (125)
Diseases linked to this target (Open Targets).
- congenital disorder of deglycosylation · score 0.76
- congenital disorder of deglycosylation 1 · score 0.68
- Alacrimia-choreoathetosis-liver dysfunction syndrome · score 0.60
- genetic disorder · score 0.53
- neurodegenerative disease · score 0.46
- Neurodevelopmental delay · score 0.43
- Alzheimer disease · score 0.37
- lysosomal storage disease · score 0.37
- multiple sclerosis · score 0.37
- Parkinson disease · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96IV0-F1 | alphafold | PREDICTED | 85.50 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96IV0.
Amino-acid sequence (654 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NGLY1?
The strongest Open Targets associations for NGLY1 are congenital disorder of deglycosylation, congenital disorder of deglycosylation 1, Alacrimia-choreoathetosis-liver dysfunction syndrome, genetic disorder and neurodegenerative disease.
How long is the NGLY1 protein?
The Homo sapiens NGLY1 protein (UniProt Q96IV0) is 654 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96IV0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96IV0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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