SH2 domain-containing adapter protein D (SHD)
Homo sapiens — UniProt Q96IW2
Data last refreshed: (UniProt release unknown)
Key facts
SH2 domain-containing adapter protein D (SHD) is a protein from Homo sapiens identified by UniProt accession Q96IW2, 340 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.
- UniProt accession: Q96IW2; gene symbol SHD.
- Organism: Homo sapiens.
- Length: 340 amino acids.
- Top disease associations (Open Targets): response to bronchodilator, vital capacity and interleukin-27 measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SH2 domain-containing adapter protein D |
|---|---|
| UniProt accession | Q96IW2 |
| Gene | SHD |
| Organism | Homo sapiens |
| Length | 340 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (32)
Diseases linked to this target (Open Targets).
- response to bronchodilator · score 0.23
- vital capacity · score 0.23
- interleukin-27 measurement · score 0.15
- Barrett's esophagus · score 0.06
- blood protein measurement · score 0.03
- Ataxia-telangiectasia · score 0.03
- neoplasm · score 0.02
- psoriasis · score 0.02
- acute kidney failure · score 0.02
- oligodendroglioma · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96IW2-F1 | alphafold | PREDICTED | 66.64 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96IW2.
Amino-acid sequence (340 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SHD?
The strongest Open Targets associations for SHD are response to bronchodilator, vital capacity, interleukin-27 measurement, Barrett's esophagus and blood protein measurement.
How long is the SHD protein?
The Homo sapiens SHD protein (UniProt Q96IW2) is 340 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96IW2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96IW2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.