Kinetochore-associated protein NSL1 homolog (NSL1)
Homo sapiens — UniProt Q96IY1
Data last refreshed: (UniProt release unknown)
Key facts
Kinetochore-associated protein NSL1 homolog (NSL1) is a protein from Homo sapiens identified by UniProt accession Q96IY1, 281 residues long. MolForge cross-references it against 0 known binders and 26 disease associations.
- UniProt accession: Q96IY1; gene symbol NSL1.
- Organism: Homo sapiens.
- Length: 281 amino acids.
- Top disease associations (Open Targets): eosinophil count, neurodegenerative disease and platelet count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Kinetochore-associated protein NSL1 homolog |
|---|---|
| UniProt accession | Q96IY1 |
| Gene | NSL1 |
| Organism | Homo sapiens |
| Length | 281 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (26)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.24
- neurodegenerative disease · score 0.21
- platelet count · score 0.19
- type 1 diabetes mellitus · score 0.17
- drug use measurement · score 0.16
- eosinophil percentage of leukocytes · score 0.12
- 22q11.2 deletion syndrome · score 0.05
- childhood onset asthma · score 0.04
- hypoparathyroidism, familial isolated, 2 · score 0.04
- Primary hypomagnesemia with secondary hypocalcemia · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96IY1-F1 | alphafold | PREDICTED | 75.93 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96IY1.
Amino-acid sequence (281 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NSL1?
The strongest Open Targets associations for NSL1 are eosinophil count, neurodegenerative disease, platelet count, type 1 diabetes mellitus and drug use measurement.
How long is the NSL1 protein?
The Homo sapiens NSL1 protein (UniProt Q96IY1) is 281 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96IY1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96IY1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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