About Epithelial-stromal interaction protein 1
Epithelial-stromal interaction protein 1 (EPSTI1) is a protein
from Homo sapiens identified by UniProt accession
Q96J88, 318 residues long.
MolForge cross-references it against 0 known binders and
87 disease associations.
Target properties
| Protein name | Epithelial-stromal interaction protein 1 |
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| UniProt accession | Q96J88 |
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| Gene | EPSTI1 |
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| Organism | Homo sapiens |
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| Length | 318 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (87)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.44
- chronic venous insufficiency · score 0.27
- prostate carcinoma · score 0.11
- prostate cancer · score 0.11
- Familial prostate cancer · score 0.11
- neoplasm · score 0.07
- oral squamous cell carcinoma · score 0.06
- coagulation factor measurement · score 0.05
- eosinophil peroxidase deficiency · score 0.05
- neutropenia-monocytopenia-deafness syndrome · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96J88-F1 | alphafold | PREDICTED | 73.77 | — |
Amino-acid sequence (318 residues)
MNTRNRVVNS GLGASPASRP TRDPQDPSGR QGELSPVEDQ REGLEAAPKG PSRESVVHAG QRRTSAYTLI APNINRRNEI QRIAEQELAN LEKWKEQNRA KPVHLVPRRL GGSQSETEVR QKQQLQLMQS KYKQKLKREE SVRIKKEAEE AELQKMKAIQ REKSNKLEEK KRLQENLRRE AFREHQQYKT AEFLSKLNTE SPDRSACQSA VCGPQSSTWK LPILPRDHSW ARSWAYRDSL KAEENRKLQK MKDEQHQKSE LLELKRQQQE QERAKIHQTE HRRVNNAFLD RLQGKSQPGG LEQSGGCWNM NSGNSWGI
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