Serine/threonine-protein kinase WNK4 (WNK4)
Homo sapiens — UniProt Q96J92
Data last refreshed: (UniProt release unknown)
Key facts
Serine/threonine-protein kinase WNK4 (WNK4) is a protein from Homo sapiens identified by UniProt accession Q96J92, 1243 residues long. MolForge cross-references it against 0 known binders and 191 disease associations.
- UniProt accession: Q96J92; gene symbol WNK4.
- Organism: Homo sapiens.
- Length: 1243 amino acids.
- Top disease associations (Open Targets): pseudohypoaldosteronism type 2B, neurodegenerative disease and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Serine/threonine-protein kinase WNK4 |
|---|---|
| UniProt accession | Q96J92 |
| Gene | WNK4 |
| Organism | Homo sapiens |
| Length | 1243 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (191)
Diseases linked to this target (Open Targets).
- pseudohypoaldosteronism type 2B · score 0.75
- neurodegenerative disease · score 0.37
- genetic disorder · score 0.19
- glioblastoma multiforme · score 0.18
- breast adenocarcinoma · score 0.16
- head and neck squamous cell carcinoma · score 0.12
- pseudohypoaldosteronism type 2E · score 0.08
- pseudohypoaldosteronism type 2D · score 0.08
- pseudohypoaldosteronism type 2C · score 0.08
- BMI-adjusted waist-hip ratio · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96J92-F1 | alphafold | PREDICTED | 57.01 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96J92.
Amino-acid sequence (1243 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with WNK4?
The strongest Open Targets associations for WNK4 are pseudohypoaldosteronism type 2B, neurodegenerative disease, genetic disorder, glioblastoma multiforme and breast adenocarcinoma.
How long is the WNK4 protein?
The Homo sapiens WNK4 protein (UniProt Q96J92) is 1243 amino acids long.
Browse: Targets: W · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96J92 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96J92 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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