Syndetin (VPS50)
Homo sapiens — UniProt Q96JG6
Data last refreshed: (UniProt release unknown)
Key facts
Syndetin (VPS50) is a protein from Homo sapiens identified by UniProt accession Q96JG6, 964 residues long. MolForge cross-references it against 0 known binders and 30 disease associations.
- UniProt accession: Q96JG6; gene symbol VPS50.
- Organism: Homo sapiens.
- Length: 964 amino acids.
- Top disease associations (Open Targets): diabetic retinopathy, Secondary microcephaly and Profound global developmental delay.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Syndetin |
|---|---|
| UniProt accession | Q96JG6 |
| Gene | VPS50 |
| Organism | Homo sapiens |
| Length | 964 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (30)
Diseases linked to this target (Open Targets).
- diabetic retinopathy · score 0.32
- Secondary microcephaly · score 0.27
- Profound global developmental delay · score 0.27
- Seizure · score 0.27
- Abnormal corpus callosum morphology · score 0.27
- Failure to thrive · score 0.27
- blood protein measurement · score 0.21
- metabolite measurement · score 0.08
- gonorrhea · score 0.05
- age at menopause · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96JG6-F1 | alphafold | PREDICTED | 70.66 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96JG6.
Amino-acid sequence (964 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with VPS50?
The strongest Open Targets associations for VPS50 are diabetic retinopathy, Secondary microcephaly, Profound global developmental delay, Seizure and Abnormal corpus callosum morphology.
How long is the VPS50 protein?
The Homo sapiens VPS50 protein (UniProt Q96JG6) is 964 amino acids long.
Browse: Targets: V · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96JG6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96JG6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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