Engulfment and cell motility protein 2 (ELMO2)
Homo sapiens — UniProt Q96JJ3
Data last refreshed: (UniProt release unknown)
Key facts
Engulfment and cell motility protein 2 (ELMO2) is a protein from Homo sapiens identified by UniProt accession Q96JJ3, 720 residues long. MolForge cross-references it against 0 known binders and 78 disease associations.
- UniProt accession: Q96JJ3; gene symbol ELMO2.
- Organism: Homo sapiens.
- Length: 720 amino acids.
- Top disease associations (Open Targets): primary intraosseous venous malformation, Primary intraosseous vascular malformation and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Engulfment and cell motility protein 2 |
|---|---|
| UniProt accession | Q96JJ3 |
| Gene | ELMO2 |
| Organism | Homo sapiens |
| Length | 720 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (78)
Diseases linked to this target (Open Targets).
- primary intraosseous venous malformation · score 0.64
- Primary intraosseous vascular malformation · score 0.60
- neurodegenerative disease · score 0.50
- cutaneous Leishmaniasis · score 0.46
- lysosomal storage disease · score 0.46
- Parkinson disease · score 0.46
- Alzheimer disease · score 0.46
- multiple sclerosis · score 0.46
- Ramon syndrome · score 0.37
- breast adenocarcinoma · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96JJ3-F1 | alphafold | PREDICTED | 88.86 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96JJ3.
Amino-acid sequence (720 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ELMO2?
The strongest Open Targets associations for ELMO2 are primary intraosseous venous malformation, Primary intraosseous vascular malformation, neurodegenerative disease, cutaneous Leishmaniasis and lysosomal storage disease.
How long is the ELMO2 protein?
The Homo sapiens ELMO2 protein (UniProt Q96JJ3) is 720 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96JJ3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96JJ3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.