Junctophilin-4 (JPH4)
Homo sapiens — UniProt Q96JJ6
Data last refreshed: (UniProt release unknown)
Key facts
Junctophilin-4 (JPH4) is a protein from Homo sapiens identified by UniProt accession Q96JJ6, 628 residues long. MolForge cross-references it against 0 known binders and 10 disease associations.
- UniProt accession: Q96JJ6; gene symbol JPH4.
- Organism: Homo sapiens.
- Length: 628 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, Chronic mucocutaneous candidosis and severe combined immunodeficiency due to CARD11 deficiency.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Junctophilin-4 |
|---|---|
| UniProt accession | Q96JJ6 |
| Gene | JPH4 |
| Organism | Homo sapiens |
| Length | 628 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (10)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.40
- Chronic mucocutaneous candidosis · score 0.03
- severe combined immunodeficiency due to CARD11 deficiency · score 0.03
- endometrial carcinoma · score 0.02
- Cirrhosis · score 0.01
- neoplasm · score 0.01
- metastatic melanoma · score 0.00
- exstrophy-epispadias complex · score 0.00
- hepatocellular carcinoma · score 0.00
- cancer · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96JJ6-F1 | alphafold | PREDICTED | 63.31 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96JJ6.
Amino-acid sequence (628 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with JPH4?
The strongest Open Targets associations for JPH4 are neurodegenerative disease, Chronic mucocutaneous candidosis, severe combined immunodeficiency due to CARD11 deficiency, endometrial carcinoma and Cirrhosis.
How long is the JPH4 protein?
The Homo sapiens JPH4 protein (UniProt Q96JJ6) is 628 amino acids long.
Browse: Targets: J · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96JJ6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96JJ6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.